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To evaluate the clinical efficacy and safety of leflunomide as a new immunosuppressive medicine in lupus nephritis LN through a meta-analysis. No language restrictions were applied. Safety data were analyzed. Eleven RCTs with Jadad score of 3 or greater were identified and included a total of patients. Cyclophosphamide was served as the control drug in all trials. Leflunomide is a promising therapy for LN treatment, primarily because of the comparable efficacy and favorable safety profile determined by this meta-analysis of RCTs.

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To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis WG. A total of 20 patients were enrolled in the trial. During a treatment period of up to 2. Disease activity remained unchanged for the duration of the study. Leflunomide appears to be safe and well tolerated for the maintenance of complete or partial remission of WG. The results of this pilot study encourage further controlled trials comparing leflunomide with alternative remission maintenance therapies.


The primary endpoint was ACR50 response at week At week 26, non-responding patients were rescued according to prespecified criteria. The primary endpoint was ACR20 response at week


Oliver (taken for 3 to 7 years) 19.02.2020

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Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. There are three general classes of drugs commonly used in the treatment of rheumatoid arthritis: non-steroidal anti-inflammatory agents NSAIDs, corticosteroids, and disease modifying anti-rheumatic drugs DMARDs.


Eleonora (taken for 2 to 5 years) 30.08.2017

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