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To evaluate the clinical efficacy and safety of leflunomide as a new immunosuppressive medicine in lupus nephritis LN through a meta-analysis. No language restrictions were applied. Safety data were analyzed. Eleven RCTs with Jadad score of 3 or greater were identified and included a total of patients. Cyclophosphamide was served as the control drug in all trials. Leflunomide is a promising therapy for LN treatment, primarily because of the comparable efficacy and favorable safety profile determined by this meta-analysis of RCTs.
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To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis WG. A total of 20 patients were enrolled in the trial. During a treatment period of up to 2. Disease activity remained unchanged for the duration of the study. Leflunomide appears to be safe and well tolerated for the maintenance of complete or partial remission of WG. The results of this pilot study encourage further controlled trials comparing leflunomide with alternative remission maintenance therapies.