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Food and Drug Administration FDA for the treatment of acne vulgaris in adults and children older than 12 years. Although dapsone has antibacterial and anti-inflammatory activity, the mechanism of action in the treatment of acne is unknown. Orally administered dapsone is known to cause hematologic reactions, including met-hemoglobinemia; hemolysis, especially in patients with glucosephosphate dehydrogenase G6PD deficiency; and agranulocytosis. Dapsone gel is FDA pregnancy category C; safety has not been established in breastfeeding mothers. Dapsone gel has not been directly compared with more established therapies e. This is higher than the cost of a g tube of tretinoin Retin-A 0.
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