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Therapy for acne vulgaris must be individualized and frequently modified depending on the types of acne lesions that predominate and the patient's response to therapy. In 2 placebo-controlled clinical studies, once-daily application of adapalene 0.
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It is also associated with Cutibacterium acnes also known as Propionibacterium acnes. Differin was later made available as 0. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. In addition, adapalene modulates the immune response by down-regulating toll-like receptor 2 TLR-2 expression and inhibiting the transcription factor activator protein 1 AP TLR-2 activation causes nuclear translocation of AP-1 and downstream pro-inflammatory gene regulation. Therefore, adapalene has a general anti-inflammatory https://www.jmir.org effect, which reduces inflammation-mediated acne symptoms.
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