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Aims: Repeated use of nonsteroidal anti-inflammatory drugs can induce changes in the redox status, including production of reactive oxygen species ROS, but the specific details of these changes remain unknown. We monitored the intra-and extracellular redox status in the stomach of rats with indomethacin-induced gastric ulcers using OMRI and investigated the relationship with gastric mucosal damage. OMRI with the membrane-permeable nitroxyl probe, 4-hydroxy-2,2,6,6-Tetramethyl-piperidineoxyl TEMPOL, demonstrated a redox change toward oxidation, which was reversed by a membrane-permeable antioxidant. Conversely, imaging with the impermeable probe, 4-Trimethylammonium-2,2,6,6-Tetramethyl-piperidineoxyl CAT-1, demonstrated little redox change. Conclusion: This method may be a very powerful tool for characterizing the pathogenesis of various diseases and may have medical applications. N2 - Aims: Repeated use of nonsteroidal anti-inflammatory drugs can induce changes in the redox status, including production of reactive oxygen species ROS, but the specific details of these changes remain unknown.
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Indomethacin and Nifedipine are commonly used medications for treatment of pre term labor. This study will compare the efficacy and adverse outcomes of oral nifedipine versus oral indomethacin for preterm labor tocolysis in an effort to identify which drug is most effective. Patients diagnosed with preterm labor who grant consent will be randomized by the pharmacy to receive oral nifedipine or oral indomethacin. Both the patient and primary medical provider will be blinded to the identity of the study drug. The patients will then receive either 25 mg of oral indomethacin every 6 hours for 48 hours, or 20 mg of oral nifedipine every 6 hours for 48 hours.