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Escitalopram oxalate is used for the acute and maintenance treatment of major depressive disorder in adults and adolescents years of age. Efficacy of escitalopram for the acute management of major depression in adults was established in 3 placebo-controlled studies of 8 weeks' duration in adult outpatients who met DSM-IV criteria for major depressive disorder. Escitalopram also was more effective than placebo in improving other aspects of depressive disorder, including anxiety, social functioning, and overall quality of life. Substantial improvement in MADRS and HAM-D scores was noted in patients receiving either dosage of escitalopram compared with those receiving placebo after weeks of therapy. In addition, escitalopram dosages of mg daily appeared to be at least as effective as racemic citalopram dosages of mg daily.
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