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Legal category: Supply through pharmacy only. Section 4. In 45 clinical studies where domperidone was used at higher dosages, for longer duration and for additional indications including diabetic gastroparesis, the frequency of adverse events apart from dry mouth was considerably higher. Cardiovascular effects. Domperidone has been associated with prolongation of the QT interval on the electrocardiogram. During post-marketing surveillance, there have been very rare cases of QT prolongation and torsades de pointes in patients taking domperidone. These reports included patients with confounding risk factors, electrolyte abnormalities and concomitant treatment which may have been contributing factors see section 4. Co-administration with levodopa. Concomitant administration of anticholinergic drugs may antagonise the anti-dyspeptic effect of Motilium. System Organ Class.

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Eighteen children aged 1 month to 12 years 8 months mean age, 4. The incidence of each of the respiratory manifestations decreased, and their cumulative score improved significantly at the end of the treatment period. Patient daily self-assessment scores also fell, but not significantly. No side effects were recorded. Domperidone provides satisfactory control of nocturnal GOR and therefore emerges as a valuable agent for the treatment of chronic GOR-associated respiratory disorders in childhood.

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From: Side Effects of Patients Annual, Prucalopride is a licensed, high-affinity serotonin 5-HT 4 understanding agonist with severe gastrointestinal prokinetic activity.

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