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Duloxetine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. It is effective in treating symptoms of depression, including physical pain associated with depression; other uses include therapy of neuropathic pain, fibromyalgia, and urinary stress incontinence. Duloxetine also inhibits serotonin uptake in human platelets, and may be associated with potentiation of bleeding. The mean elimination half-life is Specimens for therapeutic monitoring should be drawn immediately before the next scheduled dose ie, trough.
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